The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
Jan. 03, 2014
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Waldemar Priebe, Houston, TX (US);
Nicholas Donato, Sugar Land, TX (US);
Moshe Talpaz, Houston, TX (US);
Slawomir Szymanski, Houston, TX (US);
Izabela Fokt, Houston, TX (US);
Alexander Levitzki, Jerusalem, IL;
Assignee:
Board of Regents, The University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 255/44 (2006.01); C07C 255/41 (2006.01); C07C 255/42 (2006.01); C07D 213/57 (2006.01); C07D 213/61 (2006.01); A61K 31/277 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07C 255/44 (2013.01); A61K 31/277 (2013.01); A61K 45/06 (2013.01); C07C 255/41 (2013.01); C07C 255/42 (2013.01); C07D 213/57 (2013.01); C07D 213/61 (2013.01);
Abstract
The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.