The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 04, 2015
Filed:
Jan. 28, 2014
Applicant:
Signature Therapeutics, Inc., Palo Alto, CA (US);
Inventors:
Thomas E. Jenkins, Half Moon Bay, CA (US);
Craig O. Husfeld, San Mateo, CA (US);
Assignee:
Signature Therapeutics, Inc., San Carlos, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 47/00 (2006.01); A61P 23/00 (2006.01); A61P 25/04 (2006.01); A61K 47/48 (2006.01); C07D 489/02 (2006.01); C07D 489/08 (2006.01); A61K 31/485 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48346 (2013.01); A61K 31/485 (2013.01); A61K 47/48246 (2013.01); C07D 489/02 (2013.01); C07D 489/08 (2013.01);
Abstract
The embodiments provide prodrug compounds of Formulae I-XV. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug compound of Formulae I-XV that provides controlled release of an opioid. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of an opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.