The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 04, 2015

Filed:

Oct. 14, 2010
Applicants:

Maurizio Grimaldi, Birmingham, AL (US);

Judith Varady Hobrath, Pinson, AL (US);

Subramaniam Ananthan, Birmingham, AL (US);

Joseph A. Maddry, Birmingham, AL (US);

Inventors:

Maurizio Grimaldi, Birmingham, AL (US);

Judith Varady Hobrath, Pinson, AL (US);

Subramaniam Ananthan, Birmingham, AL (US);

Joseph A. Maddry, Birmingham, AL (US);

Assignee:

Southern Research Institute, Birmingham, AL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/675 (2006.01); A61K 31/427 (2006.01); A61K 31/4402 (2006.01); C07D 417/02 (2006.01); C07D 417/14 (2006.01); C07D 277/38 (2006.01); C07D 277/20 (2006.01); C07D 213/72 (2006.01);
U.S. Cl.
CPC ...
A61K 31/675 (2013.01); A61K 31/427 (2013.01);
Abstract

Methods for enhancing memory and/or learning and prevent neurodegeneration by administration of certain heterocyclic and aromatic compounds are described. The methods are particularly useful for treating patients suffering from a neurodegenerative disease such as (without limitation) Alzheimer's, Parkinsons's, Lou Gehrig's (ALS) disease or memory or learning impairment. A neuronal human cell-based assay that assess NF-kB gene up-regulation using a luciferase reporter is also provided that screens for compounds useful in methods for enhancing memory or learning.


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