The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
May. 28, 2013
Applicant:
Kineta Two, Llc, Seattle, WA (US);
Inventors:
Shawn P. Iadonato, Seattle, WA (US);
Charles L. Magness, Seattle, WA (US);
Gary Rosenberg, Danbury, CT (US);
Christina A. Scherer, Seattle, WA (US);
Thierry Guillaudeux, Rennes, FR;
Assignee:
Kineta Two, LLC, Seattle, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C12Q 1/70 (2006.01); A61K 38/45 (2006.01); C12Q 1/68 (2006.01); C07K 16/40 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12Q 1/707 (2013.01); A61K 38/45 (2013.01); C07K 16/40 (2013.01); C12N 9/1241 (2013.01); C12N 15/1137 (2013.01); C12Q 1/6876 (2013.01); C12Q 1/6883 (2013.01); C12Q 1/6888 (2013.01); C12Q 1/70 (2013.01); C12Q 2600/156 (2013.01);
Abstract
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.