The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Jun. 14, 2012
Gerald S. Jones, Jr., Norwood, MA (US);
Joseph P. St. Laurent, Lakeville, MA (US);
Scott A. Goodrich, Stoughton, MA (US);
George Maguire, Newton, MA (US);
Gerald S. Jones, Jr., Norwood, MA (US);
Joseph P. St. Laurent, Lakeville, MA (US);
Scott A. Goodrich, Stoughton, MA (US);
George Maguire, Newton, MA (US);
Chemic Laboratories Inc., Canton, MA (US);
Abstract
A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselectively reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methlTHFA; and (4) isolating (6S)-5-methylTHFA.