The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Nov. 30, 2011
Applicants:
Sandro Mauro, Rome, IT;
Daniela Fattori, Velletri, IT;
Piero D'andrea, Genzano di Roma, IT;
Amalia Cipollone, Rome, IT;
Enzo D'andrea, Genzano di Roma, IT;
Carmela Ercolano, Genzano di Roma, IT;
Inventors:
Sandro Mauro, Rome, IT;
Daniela Fattori, Velletri, IT;
Piero D'Andrea, Genzano di Roma, IT;
Amalia Cipollone, Rome, IT;
Enzo D'Andrea, Genzano di Roma, IT;
Carmela Ercolano, Genzano di Roma, IT;
Assignee:
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A., Luxembourg, LU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 17/16 (2006.01); C07D 311/58 (2006.01);
U.S. Cl.
CPC ...
C12P 17/162 (2013.01); C07D 311/58 (2013.01);
Abstract
The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.