The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Mar. 08, 2010
Applicants:
Mark A. Rubin, New York, NY (US);
Dorothee Pflueger, Zurich, CH;
David S. Rickman, New York, NY (US);
Inventors:
Mark A. Rubin, New York, NY (US);
Dorothee Pflueger, Zurich, CH;
David S. Rickman, New York, NY (US);
Assignee:
CORNELL UNIVERSITY, Ithaca, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C12N 15/62 (2006.01); C07K 14/47 (2006.01); C07K 14/82 (2006.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/62 (2013.01); C07K 14/47 (2013.01); C07K 14/82 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57434 (2013.01); A61K 38/00 (2013.01);
Abstract
An in depth analysis of prostate cancer prostatectomy samples which over-express the ERG oncogene led to the discovery of a novel gene translocation in prostate cancer, between the NDRG1 gene (N-myc downstream regulated gene 1) on chromosome 8 and the ERG oncogene on chromosome 21, leading to the expression of a chimeric NDRG1-ERG protein. Methods and compositions useful for diagnosing and treating prostate cancer characterized by NDRG1-ERG fusion are described.