The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Dec. 14, 2009
William R. Farmer, Concord, MA (US);
Jeff Bickmeier, Arlington, MA (US);
Chenfeng LU, Watertown, MA (US);
Dong-eun Chang, Newton, MA (US);
Frank Skraly, Watertown, MA (US);
Thomas Martin Ramseier, Newton, MA (US);
William R. Farmer, Concord, MA (US);
Jeff Bickmeier, Arlington, MA (US);
Chenfeng Lu, Watertown, MA (US);
Dong-Eun Chang, Newton, MA (US);
Frank Skraly, Watertown, MA (US);
Thomas Martin Ramseier, Newton, MA (US);
Metabolix, Inc., Cambridge, MA (US);
Abstract
Recombinant hosts for producing polyhydroxyalkanoates and methods of producing polyhydroxyalkanoates from renewable carbon substrates are provided. Certain recombinant hosts that produce 5 carbon chemicals such as 5-aminopentanoate (5AP), 5-hydroxyvalerate (5HV), glutarate, and 1,5 pentanediol (PDO) are also provided. One embodiment provides a recombinant host expressing a gene encoding a heterologous enzyme selected from the group consisting of a polyhydroxyalkanoate synthase and a 5-hydroxyvalerate-CoA (5HV-CoA) transferase, wherein the host produces a polymer containing 5-hydroxyvalerate. Preferably, the host expresses both a polyhydroxyalkanoate synthase and a 5HV-CoA transferase. The host can be prokaryotic or eukaryotic. A preferred prokaryotic host is. The polymers produced by the recombinant hosts can be homopolymers or copolymers of 5-hydroxyvalerate. A preferred copolymer is poly(3-hydroxybutyrate-co-5-hydroxyvalerate).