The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Sep. 22, 2014
Applicant:
Abbvie Inc., North Chicago, IL (US);
Inventors:
Cornelia Bengea, Auburn, MA (US);
Lisa M. Rives, Natick, MA (US);
Patrick Hossler, Westborough, MA (US);
Assignee:
AbbVie Inc., North Chicago, IL (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/24 (2006.01); C12N 5/00 (2006.01); C12P 21/00 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/241 (2013.01); C07K 16/00 (2013.01); C12N 5/0018 (2013.01); C12P 21/005 (2013.01); C07K 2317/14 (2013.01); C07K 2317/21 (2013.01); C07K 2317/41 (2013.01); C12N 2500/20 (2013.01); C12N 2500/34 (2013.01); C12N 2511/00 (2013.01);
Abstract
The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose.