The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Dec. 23, 2013
Applicant:
Northern Antibiotics Ltd., Helsinki, FI;
Inventors:
Martti Sakari Vaara, Helsinki, FI;
Timo Ilmari Vaara, Helsinki, FI;
Assignee:
NORTHERN ANTIBIOTICS LTD., Helsinki, FI;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 7/62 (2006.01); C12Q 1/18 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/62 (2013.01); C12Q 1/18 (2013.01); A61K 38/00 (2013.01); G01N 2500/00 (2013.01);
Abstract
The present invention relates to a polymyxin derivative wherein the derivative has a total of three positive charges at physiological pH and wherein the terminal moiety (D) of the derivative comprises a total of 1 to 5 carbon atoms The invention also relates to a method of treating a subject for a gram-negative bacterial infection by administering a polymyxin derivative of the invention in combination with a second antibacterial agent. Finally, the invention relates to a process for preparing such polymyxin derivatives.