The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Oct. 26, 2011
Jon Holbech Rasmussen, Lyngby, DK;
Jens Fomsgaard, Farum, DK;
Stefan Hansen, Copenhagen, DK;
Palle Hedengran Rasmussen, Taastrup, DK;
Wolfgang Oliver Wachs, Nykoebing Sjaelland, DK;
Jon Holbech Rasmussen, Lyngby, DK;
Jens Fomsgaard, Farum, DK;
Stefan Hansen, Copenhagen, DK;
Palle Hedengran Rasmussen, Taastrup, DK;
Wolfgang Oliver Wachs, Nykoebing Sjaelland, DK;
Ferring B.V., Hoofddorp, NL;
Abstract
The present invention relates to a liquid (or solution)-phase manufacturing process for preparing the decapeptide Degarelix, its protected precursor, and other useful intermediates. The invention further relates to polypeptides useful in the solution-phase manufacturing process and to the purification of Degarelix itself. Degarelix can be obtained by subjecting a Degarelix precursor according to formula (II): (P)AA-AA-AA-AA(P)-AA-AA(P)-AA-AA(P)-AA-AA-NH(II) or a salt or solvate thereof, to a treatment with a cleaving agent in an organic solvent, wherein Pis an amino protecting groups; preferably acetyl; Pis hydrogen or a hydroxy! protecting group, preferably a hydroxyl protecting group; Pis hydrogen or an amino protecting groups; preferably an amino protecting groups; and Pis an amino protecting group.