The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Aug. 31, 2011
P. Jeffrey Conn, Brentwood, TN (US);
Craig W. Lindsley, Brentwood, TN (US);
Shaun R. Stauffer, Brentwood, TN (US);
Carrie K. Jones, Nashville, TN (US);
Jose Manuel Bartolome-nebreda, Toledo, ES;
Susana Conde-ceide, Toledo, ES;
Gregor James Macdonald, Boorse, BE;
Manuel Jesus Alcazar Vaca, Toledo, ES;
P. Jeffrey Conn, Brentwood, TN (US);
Craig W. Lindsley, Brentwood, TN (US);
Shaun R. Stauffer, Brentwood, TN (US);
Carrie K. Jones, Nashville, TN (US);
Jose Manuel Bartolome-Nebreda, Toledo, ES;
Susana Conde-Ceide, Toledo, ES;
Gregor James Macdonald, Boorse, BE;
Manuel Jesus Alcazar Vaca, Toledo, ES;
Vanderbilt University, Nashville, TN (US);
Abstract
In one aspect, the invention relates to novel bicyclic oxazole and thiazole compounds which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ('mGluR5'); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions; and methods for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.