The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Dec. 07, 2011
Hui-ling Wang, Thousand Oaks, CA (US);
Kaustav Biswas, Agoura Hills, CA (US);
Victor J. Cee, Thousand Oaks, CA (US);
Frank Chavez, Jr., Camarillo, CA (US);
Bradley J. Herberich, Newbury Park, CA (US);
Claire L. M. Jackson, Thousand Oaks, CA (US);
Brian A. Lanman, Woodland Hills, CA (US);
Matthew Lee, Calabasas, CA (US);
Thomas Nixey, Newbury Park, CA (US);
Liping H. Pettus, Thousand Oaks, CA (US);
Anthony B. Reed, Newbury Park, CA (US);
Robert M. Rzasa, Ventura, CA (US);
Shannon Rumfelt, Camarillo, CA (US);
Andrew Tasker, Simi Valley, CA (US);
Bin Wu, Thousand Oaks, CA (US);
Ryan Wurz, Newbury Park, CA (US);
Hui-Ling Wang, Thousand Oaks, CA (US);
Kaustav Biswas, Agoura Hills, CA (US);
Victor J. Cee, Thousand Oaks, CA (US);
Frank Chavez, Jr., Camarillo, CA (US);
Bradley J. Herberich, Newbury Park, CA (US);
Claire L. M. Jackson, Thousand Oaks, CA (US);
Brian A. Lanman, Woodland Hills, CA (US);
Matthew Lee, Calabasas, CA (US);
Thomas Nixey, Newbury Park, CA (US);
Liping H. Pettus, Thousand Oaks, CA (US);
Anthony B. Reed, Newbury Park, CA (US);
Robert M. Rzasa, Ventura, CA (US);
Shannon Rumfelt, Camarillo, CA (US);
Andrew Tasker, Simi Valley, CA (US);
Bin Wu, Thousand Oaks, CA (US);
Ryan Wurz, Newbury Park, CA (US);
AMGEN INC., Thousand Oaks, CA (US);
Abstract
The invention relates to bicyclic compounds of formula (1'), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.