The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 28, 2015
Filed:
Mar. 12, 2013
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Michael F. Clarke, Palo Alto, CA (US);
Max S. Wicha, Ann Arbor, MI (US);
Muhammad Al-Hajj, Eagleville, PA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 39/395 (2006.01); A01K 67/027 (2006.01); C12N 5/095 (2010.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01); C12Q 1/68 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A01K 67/0271 (2013.01); C12N 5/0695 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5011 (2013.01); G01N 33/57492 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5152 (2013.01); A61K 2039/5158 (2013.01); C07K 14/705 (2013.01); C07K 14/70585 (2013.01); C07K 14/71 (2013.01); C07K 16/28 (2013.01); C07K 16/2863 (2013.01); C07K 16/30 (2013.01); C12N 2501/42 (2013.01); C12N 2503/00 (2013.01); C12N 2503/02 (2013.01);
Abstract
The invention provides methods for treating cancer via administering to a patient having a solid tumor a therapeutically effective amount of an antibody against Delta-like ligand 4(Dll4) or other Notch pathway components. The solid tumor may comprise solid tumor stem cells.