The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2015
Filed:
Jul. 08, 2009
Emanuel F. Petricoin, Iii, Gainesville, VA (US);
Lance A. Liotta, Bethesda, MD (US);
Virginia Espina, Rockville, MD (US);
Julia D. Wulfkuhle, Columbia, MD (US);
Emanuel F. Petricoin, III, Gainesville, VA (US);
Lance A. Liotta, Bethesda, MD (US);
Virginia Espina, Rockville, MD (US);
Julia D. Wulfkuhle, Columbia, MD (US);
George Mason Research Foundation, Inc., Fairfax, VA (US);
Abstract
The present invention provides reliable methods to identify subsets of subjects with a cancer of epithelial origin characterized by a high level of phosphorylated c-erbB2 which does not correlate with the over-expression of total c-erbB2 as measured by IHC or FISH, for selection and inclusion for c-erbB2-direct treatment and therapy. Furthermore, the present invention provides a reliable method to determine whether a subject with a cancer of epithelial origin who has been determined to be c-erbB2 positive by IHC and by FISH should be excluded from c-erbB2-direct treatment because of a non-significant level of phosphorylated c-erbB2 in epithelial tumor tissue.