The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2015
Filed:
Mar. 25, 2014
Applicant:
National Tsing Hua University, Hsinchu, TW;
Inventors:
Gwo-Bin Lee, Hsinchu, TW;
Shu-Chu Shiesh, Hsinchu, TW;
Ching-Chu Wu, Hsinchu, TW;
Hsin-I Lin, Hsinchu, TW;
Ko-Wei Chang, Hsinchu, TW;
Assignee:
NATIONAL TSING HUA UNIVERSITY, Hsinchu, TW;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01); C12N 15/115 (2010.01);
U.S. Cl.
CPC ...
G01N 33/5308 (2013.01); C12N 15/115 (2013.01); C12N 2310/16 (2013.01); G01N 2333/805 (2013.01);
Abstract
The present invention provides a Hemoglobin A1c-specific aptamer and a Hemoglobin-specific aptamer. The aptamers were selected in vitro using SELEX and a microfluidic chip system. The aptamers established low free energy, thus were more stable than conventional antibodies. The high specificity of the aptamers to Hemoglobin A1c or Hemoglobin allows them to be effectively used in diagnosis of diabetes and/or anemia.