The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2015
Filed:
Nov. 28, 2005
Harald Von Melchner, Kronberg/Taunus, DE;
Frank Schnütgen, Alzenau, DE;
Wolfgang Wurst, München, DE;
Patricia Ruiz, Berlin, DE;
Harald Von Melchner, Kronberg/Taunus, DE;
Frank Schnütgen, Alzenau, DE;
Wolfgang Wurst, München, DE;
Patricia Ruiz, Berlin, DE;
FRANKGEN BIOTECHNOLOGIE AG, Kronberg, DE;
GSF FORSCHUNGSZENTRUM FUR UMWELT UND GESUNDHEIT GMBH, Neuherberg, DE;
MPG MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V., Munich, DE;
Abstract
The present invention relates to a novel class of gene trap vector (enhanced gene trap vectors, eGTV) for efficiently identifying silent or weakly expressed target genes in mammalian genomes, methods of their production and methods for identifying and mutating target genes by using the enhanced gene trap vectors. The gene trap vectors of the present invention can also be used for inducing the expression of silent genes and enhancing the expression of weakly expressed genes. The use of the enhanced gene trap vectors for creating transgenic organisms to identify gene function and to validate pharmaceutical compounds prior to clinical applications is a further aspect of the present invention.