The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2015
Filed:
Apr. 19, 2010
Applicants:
Gregory J. Fisk, Fremont, CA (US);
Margaret S. Inokuma, San Jose, CA (US);
Inventors:
Gregory J. Fisk, Fremont, CA (US);
Margaret S. Inokuma, San Jose, CA (US);
Assignee:
Asterias Biotherapeutic, Inc., Menlo Park, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/071 (2010.01); A61K 35/39 (2015.01); A01N 65/00 (2009.01); G01N 33/50 (2006.01); C12N 5/074 (2010.01); C12N 5/0735 (2010.01); C12N 5/079 (2010.01); C12N 5/073 (2010.01); G01N 33/569 (2006.01); A61K 35/12 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0676 (2013.01); A01N 65/00 (2013.01); A61K 35/39 (2013.01); C12N 5/067 (2013.01); C12N 5/0678 (2013.01); G01N 33/507 (2013.01); G01N 33/5008 (2013.01); G01N 33/5067 (2013.01); G01N 33/5073 (2013.01); A61K 35/12 (2013.01); C12N 5/0603 (2013.01); C12N 5/0606 (2013.01); C12N 5/0607 (2013.01); C12N 5/0618 (2013.01); C12N 2500/25 (2013.01); C12N 2500/30 (2013.01); C12N 2500/36 (2013.01); C12N 2500/38 (2013.01); C12N 2500/44 (2013.01); C12N 2500/46 (2013.01); C12N 2500/62 (2013.01); C12N 2501/105 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/12 (2013.01); C12N 2501/13 (2013.01); C12N 2501/148 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/19 (2013.01); C12N 2501/33 (2013.01); C12N 2501/385 (2013.01); C12N 2501/392 (2013.01); C12N 2501/395 (2013.01); C12N 2501/41 (2013.01); C12N 2502/02 (2013.01); C12N 2502/14 (2013.01); C12N 2503/00 (2013.01); C12N 2503/02 (2013.01); C12N 2506/02 (2013.01); C12N 2510/00 (2013.01); G01N 33/5014 (2013.01); G01N 33/56966 (2013.01);
Abstract
This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research, drug screening, or regenerative medicine.