The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2015
Filed:
Mar. 02, 2011
Robert M. Jones, San Diego, CA (US);
Daniel J. Buzard, San Diego, CA (US);
Tawfik Gharbaoui, Escondido, CA (US);
Benjamin R. Johnson, San Diego, CA (US);
Michelle Kasem, Chula Vista, CA (US);
Thomas O. Schrader, San Diego, CA (US);
Scott Stirn, San Diego, CA (US);
Robert M. Jones, San Diego, CA (US);
Daniel J. Buzard, San Diego, CA (US);
Tawfik Gharbaoui, Escondido, CA (US);
Benjamin R. Johnson, San Diego, CA (US);
Michelle Kasem, Chula Vista, CA (US);
Thomas O. Schrader, San Diego, CA (US);
Scott Stirn, San Diego, CA (US);
Arena Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
The present invention relates to salts, processes, and process intermediates useful in the preparation of (R)-2-(9-chloro -7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid of Formula (Ia), salts, and crystalline forms thereof. The compound (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid has been identified as an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).