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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9085523 B1

PDFFull Text
Date of Patent:
Jul. 21, 2015

Filed:

Aug. 03, 2012

Compound for treating cartilage disorders

Applicants:

Tetsuo Obitsu, Osaka, JP;

Kousuke Tani, Osaka, JP;

Hikaru Sugihara, Osaka, JP;

Akio Nishiura, Osaka, JP;

Shinsei Fujimura, Osaka, JP;

Inventors:

Tetsuo Obitsu, Osaka, JP;

Kousuke Tani, Osaka, JP;

Hikaru Sugihara, Osaka, JP;

Akio Nishiura, Osaka, JP;

Shinsei Fujimura, Osaka, JP;

Assignee:

ONO PHARMACEUTICAL CO., LTD., Osaka, JP;

Attorney:

Sughrue Mion, PLLC

Primary Examiner:

Patrick Lewis

Int. Cl.
CPC ...
A01N 37/08 (2006.01); A61K 31/215 (2006.01); C07C 59/56 (2006.01); C07C 405/00 (2006.01); C07C 235/06 (2006.01); C07C 235/16 (2006.01); C07C 65/28 (2006.01); A61K 9/00 (2006.01); A61K 47/26 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C07C 59/56 (2013.01); A61K 9/0019 (2013.01); A61K 47/26 (2013.01); A61K 47/48969 (2013.01); C07C 65/28 (2013.01); C07C 235/06 (2013.01); C07C 235/16 (2013.01); C07C 405/00 (2013.01); C07C 2101/04 (2013.01); C07C 2101/08 (2013.01); Y10T 428/2982 (2015.01);
Abstract

The present invention provides a compound of which active |form| is represented by a formula (A). and which can be injected into a joint cavity which is an affected part of disorders and can be accumulated in the joint cavity to exert the pharmacological effect thereof in a sustained manner, for the purpose of ameliorating cartilage disorders without developing any side effect. A compound according to the present invention, which is represented by a formula (I): (wherein all of symbols are as defined in the description), is a compound that can achieve the above-mentioned purpose. This compound does not exhibit any side effect on the cardiovascular system even when the compound is administered in an effective amount for exhibiting a cartilage regeneration activity, and is therefore extremely useful as a safe and effective preventive and/or therapeutic agent for cartilage disorders. Since a suspension produced using this compound can be injected without requiring the incision of the affected part, it can reduce the burden on patients, and is extremely useful as a medicinal agent.

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