The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2015
Filed:
Feb. 03, 2012
Edward Lemke, Mannheim, DE;
Carsten Schultz, Heidelberg, DE;
Tilman Plass, Heidelberg, DE;
Sigrid Milles, Mannheim, DE;
Christine Koehler, Forst, DE;
Edward Lemke, Mannheim, DE;
Carsten Schultz, Heidelberg, DE;
Tilman Plass, Heidelberg, DE;
Sigrid Milles, Mannheim, DE;
Christine Koehler, Forst, DE;
EMBL, Heidelberg, DE;
Abstract
The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans-cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5-tetrazine group.