The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 21, 2015
Filed:
Dec. 10, 2009
Levi A. Garraway, Newton, MA (US);
Caroline Emery, Brighton, MA (US);
Carlos Garcia-echeverria, Saint-Cloud, FR;
Levi A. Garraway, Newton, MA (US);
Caroline Emery, Brighton, MA (US);
Carlos Garcia-Echeverria, Saint-Cloud, FR;
Novartis AG, Basel, CH;
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Abstract
The present invention relates to methods, compositions and kits concerning resistance to treatment with an anti-cancer agent, specifically an inhibitor of MEK. In particular embodiments, the invention concerns mutations in a MEK sequence that confer resistance to a MEK inhibitor. Identification of such mutations in a MEK sequence allows the identification and design of second-generation MEK inhibitors. Methods and kits for detecting the presence of a mutant MEK sequence in a sample are also provided.