The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Apr. 11, 2006
John Bradley, Cambridge, GB;
Jordan Pober, New Haven, CT (US);
Paul Clark, New Haven, CT (US);
Wang Min, New Haven, CT (US);
Martin Kluger, New Haven, CT (US);
John Bradley, Cambridge, GB;
Jordan Pober, New Haven, CT (US);
Paul Clark, New Haven, CT (US);
Wang Min, New Haven, CT (US);
Martin Kluger, New Haven, CT (US);
Cambridge Enterprise Limited, Cambridge, GB;
Yale University, New Haven, CT (US);
Abstract
This invention relates to the identification and characterization of specific cellular responses which are associated with tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 1 (TNFR2). Selective modulation of these tumor necrosis factor receptors (TNFRs) Selective modulations of these responses may be useful in the promotion or inhibition of cell growth, for example, in the treatment of disease conditions, including cardiovascular and kidney diseases. Therapeutic methods employed selective TNFR1 and TNFR2 modulators are provided, along with screening methods for the identification of selective TNFR1 and TNFR2 modulators useful in such methods.