The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 2015

Filed:

May. 14, 2014
Applicant:

General Electric Company, Schenectady, NY (US);

Inventors:

Kashan Ali Shaikh, Clifton Park, NY (US);

Mengli Wang, Niskayuna, NY (US);

Adriana Ines Larriera Moreno, Albany, NY (US);

Jessica Godin Karp, Niskayuna, NY (US);

Christine Lynne Pitner, Niskayuna, NY (US);

Assignee:

General Electric Company, Niskayuna, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 99/00 (2010.01); G01N 21/05 (2006.01); C12Q 1/68 (2006.01); B01L 3/00 (2006.01); B01L 9/00 (2006.01); B32B 37/00 (2006.01); B32B 37/18 (2006.01); B32B 38/00 (2006.01);
U.S. Cl.
CPC ...
G01N 21/05 (2013.01); B01L 3/5027 (2013.01); B01L 3/502707 (2013.01); C12Q 1/6841 (2013.01); B01L 9/527 (2013.01); B01L 2200/027 (2013.01); B01L 2200/0689 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0822 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/0887 (2013.01); B01L 2400/0655 (2013.01); B32B 37/0076 (2013.01); B32B 37/182 (2013.01); B32B 38/0008 (2013.01); B32B 2535/00 (2013.01); G01N 2021/058 (2013.01);
Abstract

A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the subassembly comprises a substrate layer forms a flexible optically transparent lid which is capable of bending in either direction to alter the internal dimensions of the subassembly. Methods of use are also disclosed.


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