The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 14, 2015

Filed:

May. 16, 2010
Applicants:

Kunyuan Cui, Bothell, WA (US);

Dong Liang, Everett, WA (US);

Inventors:

Kunyuan Cui, Bothell, WA (US);

Dong Liang, Everett, WA (US);

Assignee:

Agave Pharma, Incorporated, Seattle, WA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61K 36/14 (2006.01); A61K 48/00 (2006.01); C12N 15/88 (2006.01); C12N 15/87 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 9/14 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
C12N 15/88 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/1272 (2013.01); A61K 9/145 (2013.01); A61K 47/48815 (2013.01);
Abstract

This disclosure provides compositions consisting of solid mixture of cationic lipids and a polynucleotide, wherein the cationic lipid molecules form a water-insoluble ionic complex with the polynucleotide. What is also described is an anhydrous mixture of the cationic lipids and the polynucleotide solubilized in an organic or polar aprotic solvent. The anhydrous compositions are useful in preparing therapeutic formulations and in the diagnosis and treatment of diseases and conditions. The compositions are useful for delivery of agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.


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