The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Oct. 27, 2011
Michael Wayne Graham, Jindalee, AU;
Peter French, Balmain, AU;
York Yuanyuan Zhu, Palo Alto, CA (US);
Yixiang LU, Jiangshu, CN;
Tiejun LI, Jiangshu, CN;
Yuncheng Sun, Jiangshu, CN;
Xiaojun Tang, Jiangshu, CN;
LI Shan, Laval, CA;
Michael Wayne Graham, Jindalee, AU;
Peter French, Balmain, AU;
York YuanYuan Zhu, Palo Alto, CA (US);
Yixiang Lu, Jiangshu, CN;
TieJun Li, Jiangshu, CN;
Yuncheng Sun, Jiangshu, CN;
XiaoJun Tang, Jiangshu, CN;
Li Shan, Laval, CA;
BENITEC BIOPHARMA LIMITED, Balmain, New South Wales, AU;
Abstract
RNA interference (RNAi) agents and the use of the RNAi agents for treating hepatitis B infection in individuals, as well as pharmaceutical compositions containing the RNAi agents are provided. The RNAi agents, or constructs for expressing them are utilized to inhibit expression of at least one Hepatitis B virus (HBV) gene, wherein each agent comprises an effector sequence complementary to or substantially complementary to a predicted sequence transcribed from a target region. In some embodiments of the present invention, the agents have more than one effector sequence; wherein the multiple effectors may target the same region of an HBV gene, different (possibly overlapping) regions of the same gene and/or different HBV genes.