The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Dec. 09, 2009
Applicants:
Loren D. Walensky, Newton, MA (US);
Michelle L. Stewart, Brookline, MA (US);
Inventors:
Loren D. Walensky, Newton, MA (US);
Michelle L. Stewart, Brookline, MA (US);
Assignee:
Dana Farber Cancer Institute, Inc., Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61P 5/00 (2006.01); C07K 14/47 (2006.01); A61K 31/00 (2006.01); G01N 33/50 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4747 (2013.01); A61K 31/00 (2013.01); G01N 33/5011 (2013.01); G01N 33/57484 (2013.01); A61K 38/00 (2013.01);
Abstract
A series of stapled BCL-2 family peptide helices were identified as able to target the survival protein MCL-I with high affinity and a subset with unprecedented selectivity. Agents and methods for selective pharmacologic neutralization of MCL-I are provided for drug discovery and therapeutic uses, including use in overcoming the apoptotic resistance of cancer and other diseases associated with impaired cell death.