The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Jan. 28, 2010
Applicants:
Yaohuang KE, San Francisco, CA (US);
Guo-liang Yu, Berkeley, CA (US);
Inventors:
Yaohuang Ke, San Francisco, CA (US);
Guo-Liang Yu, Berkeley, CA (US);
Assignee:
EPITOMICS, INC., Burlingame, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2006.01); C40B 30/04 (2006.01); C07K 16/00 (2006.01); C07K 16/24 (2006.01);
U.S. Cl.
CPC ...
C07K 16/005 (2013.01); C07K 16/241 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C12Q 1/6881 (2013.01);
Abstract
A method of obtaining nucleic acid encoding a plurality of antibodies is provided. In certain embodiments, the method comprises obtaining from an immunized animal nucleic acid encoding the amino acid sequence of the heavy and light chains of a second antibody that binds to the antigen as a first antibody and differs in amino acid sequence to the first antibody, wherein the obtaining is done by amplification using: i. a first primer pair that includes oligonucleotides are complementary to CDR-encoding regions first antibody.