The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Sep. 12, 2014
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Shaomeng Wang, Saline, MI (US);
Shanghai Yu, Ann Arbor, MI (US);
Wei Sun, Yunnan, CN;
Sanjeev Kumar, Ann Arbor, MI (US);
Duxin Sun, Ann Arbor, MI (US);
Peng Zou, Ann Arbor, MI (US);
Donna McEachern, Ann Arbor, MI (US);
Yujun Zhao, Ann Arbor, MI (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/10 (2006.01); A61K 31/407 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01); C07D 491/107 (2006.01); C07D 495/10 (2006.01); C07D 471/20 (2006.01); C07F 9/6561 (2006.01);
U.S. Cl.
CPC ...
C07D 487/10 (2013.01); A61K 31/407 (2013.01); A61K 31/454 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07D 471/20 (2013.01); C07D 491/107 (2013.01); C07D 495/10 (2013.01); C07F 9/6561 (2013.01);
Abstract
Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.