The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Feb. 22, 2013
China National Medicines Guorui Pharmaceutical Co., Ltd., Huianan, Anhui, CN;
Shanghai Institute of Pharmaceutical Industry, Shanghai, CN;
Fuli Zhang, Shanghai, CN;
Bin Liang, Shanghai, CN;
Chunbo Yang, Shanghai, CN;
Chonghao Liu, Shanghai, CN;
Yang Gao, Shanghai, CN;
Jian Wang, Anhui, CN;
Min Jiang, Anhui, CN;
CHINA NATIONAL MEDICINES GUORUI PHARMACEUTICAL CO., LTD., Anhui, CN;
SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, Shanghai, CN;
Abstract
A method for preparing a Rivaroxaban intermediate I is presented, including the following step: in a non-protonic solvent, under the effect of lewis acid, performing cyclization reaction on 4-(4-phenyl isocyanate)morpholine-3-ketone (II) and (S)-epoxy compound (III), the reaction temperature ranging from 20° C. to 60° C., where R is amino replaced by amino protecting group. The preparation method of the present invention has a mild condition, a simple process, a low cost, and high efficiency; the product is easy to purify and the method is applicable to industrial production.