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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9079859 B1

PDFFull Text
Date of Patent:
Jul. 14, 2015

Filed:

Jan. 20, 2012

Synthetic lethal targeting of glucose transport

Applicants:

John Irwin, San Rafael, CA (US);

Patrick Sutphin, Boston, MA (US);

Denise Chan, San Francisco, CA (US);

Sandra Turcotte, Repentigny, CA;

Amato Giaccia, Stanford, CA (US);

Edwin Lai, Menlo Park, CA (US);

Olga Razorenova, Menlo Park, CA (US);

Michael Patrick Hay, Auckland, NZ;

Muriel Bonnet, Auckland, NZ;

Connie Sun, Palo Alto, CA (US);

Raymond Tabibiazar, Portola Valley, CA (US);

Inventors:

John Irwin, San Rafael, CA (US);

Patrick Sutphin, Boston, MA (US);

Denise Chan, San Francisco, CA (US);

Sandra Turcotte, Repentigny, CA;

Amato Giaccia, Stanford, CA (US);

Edwin Lai, Menlo Park, CA (US);

Olga Razorenova, Menlo Park, CA (US);

Michael Patrick Hay, Auckland, NZ;

Muriel Bonnet, Auckland, NZ;

Connie Sun, Palo Alto, CA (US);

Raymond Tabibiazar, Portola Valley, CA (US);

Assignees:

AUCKLAND UNISERVICES LIMITED, Auckland, NZ;

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, Palo Alto, CA (US);

RUGA CORPORATION, Palo Alto, CA (US);

Attorney:

Cooley LLP

Primary Examiner:

Raymond Henley, III

Int. Cl.
CPC ...
A61K 31/47 (2006.01); A61K 31/44 (2006.01); C07D 401/12 (2006.01); C07D 413/04 (2006.01); C07D 277/46 (2006.01); C07D 231/18 (2006.01); C07D 213/75 (2006.01); A61K 31/415 (2006.01); A61K 31/422 (2006.01); A61K 31/4245 (2006.01); A61K 31/426 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); A61K 31/4412 (2006.01); A61K 31/443 (2006.01); A61K 31/4436 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/4965 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); C07D 215/58 (2006.01); C07D 231/42 (2006.01); C07D 277/54 (2006.01); C07D 413/12 (2006.01); G01N 33/50 (2006.01);
U.S. Cl.
CPC ...
C07D 213/75 (2013.01); A61K 31/415 (2013.01); A61K 31/422 (2013.01); A61K 31/426 (2013.01); A61K 31/4245 (2013.01); A61K 31/44 (2013.01); A61K 31/4402 (2013.01); A61K 31/443 (2013.01); A61K 31/444 (2013.01); A61K 31/4406 (2013.01); A61K 31/4409 (2013.01); A61K 31/4412 (2013.01); A61K 31/4436 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/47 (2013.01); A61K 31/496 (2013.01); A61K 31/4965 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); C07D 215/58 (2013.01); C07D 231/42 (2013.01); C07D 277/54 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01); G01N 33/5008 (2013.01);
Abstract

The present invention provides methods for inhibiting growth and proliferation of HIF pathway proficient cells by administering GLUT1 inhibitors of the invention to HIF pathway proficient cells.

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