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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9079852 B1

PDFFull Text
Date of Patent:
Jul. 14, 2015

Filed:

Apr. 15, 2013

Nmda receptor antagonists for neuroprotection

Applicants:

Dennis C. Liotta, Atlanta, GA (US);

James P. Snyder, Atlanta, GA (US);

Stephen F. Traynelis, Decatur, GA (US);

Lawrence Wilson, Atlanta, GA (US);

Cara Mosley, Atlanta, GA (US);

Raymond J. Dingledine, Atlanta, GA (US);

Scott Myers, Atlanta, GA (US);

Yesim Altas Tahirovic, Decatur, GA (US);

Inventors:

Dennis C. Liotta, Atlanta, GA (US);

James P. Snyder, Atlanta, GA (US);

Stephen F. Traynelis, Decatur, GA (US);

Lawrence Wilson, Atlanta, GA (US);

Cara Mosley, Atlanta, GA (US);

Raymond J. Dingledine, Atlanta, GA (US);

Scott Myers, Atlanta, GA (US);

Yesim Altas Tahirovic, Decatur, GA (US);

Assignees:

Emory University, Atlanta, GA (US);

NeurOp, Inc., Atlanta, DE (US);

Attorney:

King & Spalding

Primary Examiner:

Kamal Saeed

Assistant Examiner:

Janet L Coppins

Int. Cl.
CPC ...
A61K 31/421 (2006.01); A61K 31/4166 (2006.01); A61K 31/495 (2006.01); C07D 241/04 (2006.01); C07D 263/18 (2006.01); C07D 233/08 (2006.01); C07D 209/34 (2006.01); C07C 217/20 (2006.01); C07C 235/20 (2006.01); C07C 311/08 (2006.01); C07D 215/227 (2006.01); C07D 233/34 (2006.01); C07D 235/26 (2006.01); C07D 263/58 (2006.01); C07D 295/088 (2006.01); C07D 211/52 (2006.01); C07D 213/74 (2006.01); C07D 233/32 (2006.01);
U.S. Cl.
CPC ...
C07D 209/34 (2013.01); C07C 217/20 (2013.01); C07C 235/20 (2013.01); C07C 311/08 (2013.01); C07D 211/52 (2013.01); C07D 213/74 (2013.01); C07D 215/227 (2013.01); C07D 233/32 (2013.01); C07D 233/34 (2013.01); C07D 235/26 (2013.01); C07D 263/58 (2013.01); C07D 295/088 (2013.01);
Abstract

Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain injury, epilepsy, and related neurologic events or neurodegeneration. Compounds are of the general Formula I, or a pharmaceutically acceptable salt, ester, prodrug or derivative thereof are provided: wherein:

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