The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Aug. 19, 2013
Applicant:
The Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Eric N. Olson, Dallas, TX (US);
Eva van Rooij, Utrecht, NL;
Assignee:
The Board of Regents, the University of Texas System, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 45/06 (2006.01); A01K 67/027 (2006.01); C12N 15/113 (2010.01); A61K 31/7105 (2006.01);
U.S. Cl.
CPC ...
A61K 45/06 (2013.01); A01K 67/0275 (2013.01); A61K 31/7105 (2013.01); C12N 15/113 (2013.01); A01K 2207/05 (2013.01); A01K 2217/058 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0375 (2013.01); C12N 2310/113 (2013.01); C12N 2310/14 (2013.01); C12N 2330/10 (2013.01); C12N 2830/008 (2013.01);
Abstract
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of cardiomyocytes. Strategies to block expression of the miR-15 family in the heart as a treatment for diverse cardiac disease are provided.