The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 14, 2015
Filed:
Dec. 05, 2013
St. Jude Children's Research Hospital, Memphis, TN (US);
Flanders Interuniversity Institute for Biotechnology Vib, Ghent, BE;
Universiteit Gent, Ghent, BE;
Leiden University Medical Center, Leiden, NL;
Michael A. Dyer, Memphis, TN (US);
Jean-Christophe Marine, Erbisoeul, BE;
Aart Gerrit Jochemsen, Leiden, NL;
St. Jude Children's Research Hospital, Memphis, TN (US);
Flanders Interuniversity Institute for Biotechnology, Ghent, BE;
Universiteit Gent, Ghent, BE;
Leiden University Medical Center, Leiden, NL;
Abstract
It has now been found that the p53 pathway is inactivated in ocular cancers such as retinoblastoma. As such, the present invention is a method for inducing ocular cancer cell death using a p53 activator. In particular embodiments, the p53 activator blocks the interaction between DM2 or DMX and p53. As the p53 activator induces ocular cancer cell death, a method for preventing or treating ocular cancer is also provided.