The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 07, 2015

Filed:

Oct. 21, 2011
Applicants:

Tae-hyun Yoon, Seoul, KR;

Song-hee Lee, Seoul, KR;

Dong-wook Kwon, Seoul, KR;

Jong-hoon Park, Seoul, KR;

Hyun-ju Yoo, Seoul, KR;

Hyun-woo Nho, Seoul, KR;

Inventors:

Tae-Hyun Yoon, Seoul, KR;

Song-Hee Lee, Seoul, KR;

Dong-Wook Kwon, Seoul, KR;

Jong-Hoon Park, Seoul, KR;

Hyun-Ju Yoo, Seoul, KR;

Hyun-Woo Nho, Seoul, KR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12Q 1/18 (2006.01); G01N 21/64 (2006.01); G01N 21/29 (2006.01); G01N 15/14 (2006.01); G01N 15/04 (2006.01); G01N 33/50 (2006.01); B82Y 5/00 (2011.01); B82Y 35/00 (2011.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1475 (2013.01); G01N 15/04 (2013.01); G01N 15/147 (2013.01); G01N 15/1484 (2013.01); G01N 21/6458 (2013.01); G01N 21/648 (2013.01); G01N 33/5014 (2013.01); G01N 2015/0038 (2013.01); G01N 2015/0092 (2013.01); G01N 2015/1075 (2013.01); G01N 2015/1486 (2013.01); G01N 2015/1497 (2013.01); G01N 2510/00 (2013.01);
Abstract

The present invention relates to a method for the toxicity assessment of nano-materials, and more specifically, it is relates to an objective, reproducible and accurate assessment method for the unbiased toxicity testings of nano-materials, which minimize artifacts of the conventional methods for the toxicity assessment of the nano-materials by considering the dose characteristics of the nano-material itself using Selective multi-Plane Illumination Microcopy (SPIM); and the response characteristics of the nano-material using the improved or novel cellular responses assessment methods for nano-materials (e.g., modified MTT assay using image cytometric analysis, normal-inverted exposure apparatus, and modified flow cytometry), and a system and an apparatus thereof.


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