The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 07, 2015

Filed:

May. 08, 2012
Applicants:

Chaur-jong HU, Taipei, TW;

Po-ting Chen, Taipei, TW;

Rita P.-y. Chen, Taipei, TW;

Steven Sheng-shih Wang, Taipei, TW;

Inventors:

Chaur-Jong Hu, Taipei, TW;

Po-Ting Chen, Taipei, TW;

Rita P.-Y. Chen, Taipei, TW;

Steven Sheng-Shih Wang, Taipei, TW;

Assignee:

ACADEMIA SINICA, Taipei, TW;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/235 (2006.01); C12Q 1/37 (2006.01); C07C 49/248 (2006.01); C07C 59/84 (2006.01); C07C 59/90 (2006.01); C07K 7/06 (2006.01); C07C 49/255 (2006.01); C07C 49/235 (2006.01); C07C 225/22 (2006.01); C12Q 1/02 (2006.01); G01N 33/50 (2006.01); C07C 49/223 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/37 (2013.01); C07K 7/06 (2013.01); C07C 49/255 (2013.01); C07C 59/90 (2013.01); C07C 49/248 (2013.01); C07C 49/235 (2013.01); C07C 225/22 (2013.01); C12Q 1/025 (2013.01); A61K 31/235 (2013.01); G01N 33/5058 (2013.01); G01N 2333/4709 (2013.01); G01N 2500/00 (2013.01); G01N 2800/2821 (2013.01); C07C 49/223 (2013.01); C07K 14/4711 (2013.01);
Abstract

A method of enhancing neprilysin activity and/or degrading amyloid-β peptides and/or oligomers in a subject with Alzheimer's disease is disclosed. The method comprises administering to the subject a compound selected from the group consisting of in a therapeutically effective amount to enhance the neprilysin activity and/or degrade the amyloid-β peptides and oligomers in the subject. Methods of improving symptoms and/or retarding progression of Alzheimer's disease and prophylactic treatment and/or treatment of Alzheimer's disease are also disclosed.


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