The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 07, 2015

Filed:

Aug. 27, 2012
Applicants:

Amato J. Giaccia, Stanford, CA (US);

Erinn Bruno Rankin, Waltham, MA (US);

Jennifer R. Cochran, Stanford, CA (US);

Douglas Jones, Cambridge, MA (US);

Mihalis Kariolis, Stanford, CA (US);

Katherine Fuh, Palo Alto, CA (US);

Yu Miao, Sunnyvale, CA (US);

Inventors:

Amato J. Giaccia, Stanford, CA (US);

Erinn Bruno Rankin, Waltham, MA (US);

Jennifer R. Cochran, Stanford, CA (US);

Douglas Jones, Cambridge, MA (US);

Mihalis Kariolis, Stanford, CA (US);

Katherine Fuh, Palo Alto, CA (US);

Yu Miao, Sunnyvale, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C12N 9/12 (2006.01); A61K 38/45 (2006.01); C07K 16/22 (2006.01); A61K 45/06 (2006.01); C07K 14/71 (2006.01);
U.S. Cl.
CPC ...
C12N 9/12 (2013.01); A61K 38/45 (2013.01); C07K 16/22 (2013.01); A61K 45/06 (2013.01); C07K 2319/30 (2013.01); C07K 14/71 (2013.01);
Abstract

Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6.


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