The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Jun. 04, 2009
Applicants:
James Bradner, Cambridge, MA (US);
Raymond Moellering, Cambridge, MA (US);
Gregory L. Verdine, Newton, MA (US);
Inventors:
James Bradner, Cambridge, MA (US);
Raymond Moellering, Cambridge, MA (US);
Gregory L. Verdine, Newton, MA (US);
Assignees:
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 7/00 (2006.01); A61K 38/00 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); A61K 38/00 (2013.01);
Abstract
Stably cross-linked a polypeptides related to human MAML are described. These cross-linked polypeptides contain at least two modified amino acids that together form an internal cross-link or tether that can help to stabilize the alpha-helical secondary structure that is thought to be important for binding of MAML peptides to the Notch transcription complex, a complex that includes ICN and CSL.