The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Apr. 04, 2011
Yoav Paas, Nes Ziona, IL;
Ilya Pittel, Brookline, MA (US);
Uri Nir, Moshav Gimzo, IL;
Barak Ben-david, Karney Shomron, IL;
Yoav Paas, Nes Ziona, IL;
Ilya Pittel, Brookline, MA (US);
Uri Nir, Moshav Gimzo, IL;
Barak Ben-David, Karney Shomron, IL;
Bar-llan University, Ramat-Gan, IL;
Abstract
An isolated pore-forming polypeptide is disclosed which comprises a naturally-occurring plugging module and a naturally-occurring pore domain, wherein at least one amino acid of the pore-forming polypeptide is mutated to generate a protease cleavage site, serving to at least partially remove the plugging module from the pore domain. The pore forming polypeptides may be inserted into an encapsulating particle and positioned such that it is capable of forming a pore through the lipid layer of the particle in a presence of the protease.