The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Mar. 24, 2014
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
Nancy Klauber DeMore, Durham, NC (US);
Cam Patterson, Chapel Hill, NC (US);
Rajendra Bhati, Durham, NC (US);
Bradley G. Bone, Apex, NC (US);
Assignee:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C12P 21/08 (2006.01); C07K 16/00 (2006.01); A61K 38/00 (2006.01); C07K 16/18 (2006.01); A61K 38/13 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01); C12N 15/113 (2010.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); A61K 38/13 (2013.01); C07K 16/28 (2013.01); C07K 16/40 (2013.01); C07K 2316/96 (2013.01); C07K 2317/34 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); G01N 33/57415 (2013.01); G01N 2800/00 (2013.01);
Abstract
The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of angiogenesis and the diagnosis and treatment of angiogenesis-related diseases such as cancer.