The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Apr. 27, 2012
Dirk Leysen, Diepenbeek, BE;
Olivier Defert, Diepenbeek, BE;
Sandro Boland, Diepenbeek, BE;
JO Alen, Diepenbeek, BE;
Arnaud Pierre Jean Bourin, Diepenbeek, BE;
Dirk Leysen, Diepenbeek, BE;
Olivier Defert, Diepenbeek, BE;
Sandro Boland, Diepenbeek, BE;
Jo Alen, Diepenbeek, BE;
Arnaud Pierre Jean Bourin, Diepenbeek, BE;
Amakem NV, Diepenbeek, BE;
Abstract
The present invention relates to new kinase inhibitors of Formula (I), wherein X is oxygen, —NH—, or a direct bond; Y is —NH— or a direct bond; n is an integer from 0 to 4; m is an integer from 0 to 4; Cy represents a bivalent radical consisting of a satured (poly)cycle, including fused, bi-, spiro or bridged carbocycles and heterocycles; in particular selected from the group consisting of: Formula (II), Ar is selected from the group comprising: Formula (III), Ris hydrogen or methyl; Ris hydrogen, methyl, halogen, or alkynyl; Ris an aryl or heteroaryl more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.