The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Dec. 27, 2011
Hadas Reuveni, Har-Adar, IL;
Alexander Levitzki, Jerusalem, IL;
Hadas Reuveni, Har-Adar, IL;
Alexander Levitzki, Jerusalem, IL;
Abstract
The present invention provides compounds of formula (1) acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as anti-cancer agents for preventions and treatments of PK- and RK-related disorders, in particular cancer. (I) wherein A is H or CN; Z is S, SO or S0; X, X, X, X, X, Yand Yare each independently selected from H, halogen, alkyl, haloalkyl and OR; and Yand Yare each OR, wherein each Ris independently H, C-Calkyl, acyl, —(CHCH0)wherein n is an integer of 1 to 20, or a functional group that gives rise to hydroxyl upon hydrolysis.