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For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9073871 B1

PDFFull Text
Date of Patent:
Jul. 07, 2015

Filed:

Aug. 28, 2014

Glucagon receptor modulators

Applicant:

Pfizer Inc., New York, NY (US);

Inventors:

Gary Erik Aspnes, Rockville, RI (US);

Mary Theresa Didiuk, Madison, CT (US);

Kevin James Filipski, Reading, MA (US);

Angel Guzman-Perez, Belmont, MA (US);

Esther Cheng Yin Lee, Brookline, MA (US);

Jeffrey Allen Pfefferkorn, Acton, MA (US);

Benjamin Dawson Stevens, Cambridge, MA (US);

Meihua Mike Tu, Acton, MA (US);

Assignee:

Pfizer Inc., New York, NY (US);

Attorney:

James T. Wasicak

Primary Examiner:

Kamal Saeed

Assistant Examiner:

Janet L Coppins

Int. Cl.
CPC ...
A61K 31/415 (2006.01); C07D 231/12 (2006.01); C07D 207/34 (2006.01); C07D 231/14 (2006.01); C07D 231/16 (2006.01); C07D 231/18 (2006.01); C07D 231/54 (2006.01); C07D 231/56 (2006.01); C07D 233/61 (2006.01); C07D 233/64 (2006.01); C07D 233/68 (2006.01); C07D 233/70 (2006.01); C07D 233/84 (2006.01); C07D 249/06 (2006.01); C07D 249/08 (2006.01); C07D 261/08 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 487/04 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 231/12 (2013.01); C07D 207/34 (2013.01); C07D 231/14 (2013.01); C07D 231/16 (2013.01); C07D 231/18 (2013.01); C07D 231/54 (2013.01); C07D 231/56 (2013.01); C07D 233/61 (2013.01); C07D 233/64 (2013.01); C07D 233/68 (2013.01); C07D 233/70 (2013.01); C07D 233/84 (2013.01); C07D 249/06 (2013.01); C07D 249/08 (2013.01); C07D 261/08 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 487/04 (2013.01); C07D 403/12 (2013.01);
Abstract

The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R, R, R, A, A, A, A, L, B, B, Band Bare as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.

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