The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Sep. 24, 2013
Otsuka Pharmaceutical Co., Ltd., Tokyo, JP;
Kazumi Kondo, Osaka, JP;
Yasuhiro Menjo, Osaka, JP;
Takahiro Tomoyasu, Osaka, JP;
Shin Miyamura, Osaka, JP;
Yuso Tomohira, Osaka, JP;
Takakuni Matsuda, Osaka, JP;
Keigo Yamada, Osaka, JP;
Yusuke Kato, Osaka, JP;
OTSUKA PHARMACEUTICAL CO., LTD., Tokyo, JP;
Abstract
The present invention provides a benzazepine compound that can maintain for a long period of time the blood level of tolvaptan enabling to provide the desired pharmaceutical effects. The benzazepine compound of the present invention is represented by general formula (1) wherein Rrepresents a —CO—(CH)—CORgroup (wherein n is an integer of 1 to 4, and Ris (2-1) a hydroxy group; (2-2) a lower alkoxy group optionally substituted with a hydroxy group, a lower alkanoyl group, a lower alkanoyloxy group, a lower alkoxycarbonyloxy group, a cycloalkyloxycarbonyloxy group, or 5 -methyl-2-oxo-1,3-dioxol-4-yl; or (2-3) an amino group optionally substituted with a hydroxy-lower alkyl group), or the like.