The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 07, 2015

Filed:

May. 25, 2012
Applicants:

Alan S. Verkman, San Francisco, CA (US);

Puay-wah Phuan, San Francisco, CA (US);

Mark J. Kurth, Davis, CA (US);

John Knapp, Davis, CA (US);

Inventors:

Alan S. Verkman, San Francisco, CA (US);

Puay-Wah Phuan, San Francisco, CA (US);

Mark J. Kurth, Davis, CA (US);

John Knapp, Davis, CA (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); C07D 215/54 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
C07D 215/54 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 401/12 (2013.01); A61K 31/44 (2013.01);
Abstract

The present disclosure provides pharmaceutical compositions, pharmaceutical preparations and methods for increasing activity of a mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR). The pharmaceutical compositions, pharmaceutical preparations and methods are useful for the study and treatment of disorders associated with mutant-CFTR, such as cystic fibrosis. The pharmaceutical compositions and pharmaceutical preparations may include one or more cyanoquinoline-containing compounds of the embodiments, or an analog or derivative thereof.


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