The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Dec. 04, 2013
Joseph P. Errico, Warren, NJ (US);
Joseph P. Errico, Warren, NJ (US);
Benjamin Mugrage, Cranbury, NJ (US);
Ignatius Turchi, Yardley, PA (US);
Matthew Sills, Berkeley Heights, NJ (US);
Jane Ong, Franklin Park, NJ (US);
John Allocco, Staten Island, NY (US);
Pam Wines, Manalapan, NJ (US);
Other;
Abstract
Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR.