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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9073825 B1

PDFFull Text
Date of Patent:
Jul. 07, 2015

Filed:

Aug. 16, 2012

Methods and intermediates for preparing macrolactams

Applicants:

Nobuyoshi Yasuda, Mountainside, NJ (US);

Jeffrey T. Kuethe, Somerset, NJ (US);

Guy Humphrey, Hillsborough, NJ (US);

Gregory L. Beutner, Green Brook, NJ (US);

Yong-li Zhong, Edison, NJ (US);

Edward Cleator, Hoddesdon, GB;

Carl Baxter, Hoddesdon, GB;

Inventors:

Nobuyoshi Yasuda, Mountainside, NJ (US);

Jeffrey T. Kuethe, Somerset, NJ (US);

Guy Humphrey, Hillsborough, NJ (US);

Gregory L. Beutner, Green Brook, NJ (US);

Yong-Li Zhong, Edison, NJ (US);

Edward Cleator, Hoddesdon, GB;

Carl Baxter, Hoddesdon, GB;

Assignees:

Merck Sharp & Dohme Limited, Hertfordshire, GB;

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Julie M. Lake

Laura M. Ginkel

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
A01N 43/04 (2006.01); A01N 43/42 (2006.01); C07C 35/04 (2006.01); C07K 5/083 (2006.01); C07D 403/12 (2006.01); C07D 498/16 (2006.01); C07K 5/12 (2006.01); C07C 67/14 (2006.01); C07C 69/013 (2006.01); C07C 69/12 (2006.01); C07C 269/04 (2006.01); C07C 271/34 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07C 35/04 (2013.01); A61K 38/00 (2013.01); C07K 5/0808 (2013.01); C07D 403/12 (2013.01); C07D 498/16 (2013.01); C07K 5/126 (2013.01); C07C 67/14 (2013.01); C07C 69/013 (2013.01); C07C 69/12 (2013.01); C07C 269/04 (2013.01); C07C 271/34 (2013.01);
Abstract

A first aspect of the present invention describes a compound selected from group consisting of: wherein R is either H, C(O)R, or C(O)NHCH(X)COOH; provided that X is a C-Calkyl, or a C-Ccycloalkyl and Ris a Calkyl or aryl; These compounds are used to make Compound A

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