The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9073813 B1

PDF
Full Text
Expired
Date of Patent:
Jul. 07, 2015

Filed:

Jan. 03, 2013
Applicants:

Instytut Farmaceutyczny, Warsaw, PL;

Warszawski Uniwersytet Medyczny, Warsaw, PL;

Inventors:

Mariusz Gruza, Warsaw, PL;

Oliwia Zegrocka-Stendel, Lomianki, PL;

Tomasz Giller, Lodz, PL;

Grzegorz Grynkiewicz, Lomianki, PL;

Marta Laszcz, Warsaw, PL;

Kamil Jatczak, Plock, PL;

Assignees:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C 29/09 (2006.01); C07C 35/44 (2006.01); C07C 29/74 (2006.01); C07C 29/78 (2006.01); C07C 29/10 (2006.01); C07C 31/27 (2006.01); C07J 63/00 (2006.01);
U.S. Cl.
CPC ...
C07C 29/095 (2013.01); C07C 29/74 (2013.01); C07C 29/78 (2013.01); C07C 31/278 (2013.01); C07J 63/00 (2013.01); C07C 35/44 (2013.01);
Abstract

A process for the preparation of protoescigenin by hydrolysis of escin isolated from. The process includes the following steps: a two-step hydrolysis first under acidic and then basic conditions, enrichment of the crude mixture of sapogenins with protoescigenin, an isolation of the mixture of sapogenins in a solid form, and a purification of the obtained solid and isolation of high purity protoescigenin. The invention also relates to protoescigenin monohydrate in a crystalline form and the preparation thereof. Protoescigenin is a polyhydroxy aglycone, which can be used as a synthon in the chemical modifications of naturally occurring saponins.


Find Patent Forward Citations

Gruza, Mariusz. (2015). Process for the preparation of protoescigenin (U.S. Patent No. 9073813). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9073813

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