The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Sep. 30, 2009
Applicants:
Koichi Takahashi, Machida, JP;
Tadashi Morikawa, Machida, JP;
Tadao Yamazaki, Kita-ku, JP;
Masaki Shibata, Gotenba, JP;
Inventors:
Koichi Takahashi, Machida, JP;
Tadashi Morikawa, Machida, JP;
Tadao Yamazaki, Kita-ku, JP;
Masaki Shibata, Gotenba, JP;
Assignee:
DENKI KAGAKU KOGYO KABUSHIKI KAISHA, Tokyo, JP;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/715 (2006.01); A01N 43/90 (2006.01); A61K 31/519 (2006.01); A61K 47/48 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/4823 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 45/06 (2013.01);
Abstract
A crosslinking reaction and a reaction for reducing molecular weight that take place in a hyaluronic acid-methotrexate conjugate upon irradiation with light are suppressed to improve the photostability of the conjugate. Specifically, a substance having a quenching effect and/or a radical scaveng effect is added to a pharmaceutical composition containing the hyaluronic acid-methotrexate conjugate.