The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 07, 2015
Filed:
Nov. 18, 2011
Applicants:
Barbara B. Kahn, Cambridge, MA (US);
Qin Yang, Brookline, MA (US);
Daniel Kraus, Wurzberg, DE;
Inventors:
Assignee:
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 31/712 (2006.01); C12N 9/10 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
A61K 31/712 (2013.01); C12N 15/1137 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 9/1007 (2013.01); C12Y 201/01001 (2013.01); A61K 39/3955 (2013.01);
Abstract
The present invention, in various embodiments, relates to methods of inhibiting NNMT production or activity in a cell, and methods of treating or preventing obesity or a related metabolic condition in a subject in need thereof, comprising administering a nicotinamide N-methyltransferase (NNMT) antagonist. The invention further provides methods of identifying NNMT antagonists useful for treating obesity and related metabolic disorders.